Another new area of acne research that is proving promising is using
antibiotics for a period of a few months to start a successful treatment
regimen, then replacing them with other non-antibiotic medications to
maintain results over time. Dr. Baldwin explained that this "step-down"
approach is important, as an increasing concern of long-term antibiotic
use is that bacteria are evolving to become resistant to these medications
- prompting dermatologists to seek alternative therapies in order to get
their patients off of oral antibiotics as soon as possible. Recent clinical
studies using the step-down approach from antibiotics and a topical retinoid
to topical retinoids alone have shown positive results in maintaining
improvement in acne patients, despite the abrupt discontinuation of oral
antibiotics.